SYNTHESIS OF SOME QUINAZOLIN-4-ONE SERIES HETEROCYCLIC COMPOUNDS AND THEIR BIOLOGICAL ACTIVITIES

Description

It is very interesting to conduct fundamental research with heterocyclic compounds containing several active reaction centers in the molecule. This is because different isomeric products can be formed from one or another reaction center, and product synthesis is focused on only one reaction center. Therefore, it is important to correctly choose the factors affecting the product type and productivity (solvent, temperature, type and amount of reactants) when carrying out such reactions. In particular, in the alkylation of compounds with an amide group among organic substances, the reaction proceeds in different directions. Therefore, in such compounds, the reaction proceeds along the path of transition to the oxygen atom or to the nitrogen atom. Such systems can exist in various tautomeric forms: amide, imine, and enol. Therefore, they enter into electrophilic exchange reactions differently and can give isomeric products of different structures. In the monograph, the methylation reactions of quinazolin-4-one and -thiones and their homologues in various solvents were studied, the synthesized new substances were proven and analyzed using modern physical research methods.