QUINAZOLINES: CHEMISTRY, SYNTHESIS, AND BIOLOGICAL ACTIVITY

Description

Quinazoline derivatives constitute a prominent class of heterocyclic compounds with considerable importance in modern organic and medicinal chemistry. Due to their structural diversity and synthetic accessibility, these compounds exhibit a broad range of biological activities, including anticancer, antimicrobial, antiviral, anti-inflammatory, antitubercular, and tyrosine kinase inhibitory effects. This book presents a comprehensive overview of quinazoline chemistry, focusing on structural features, electronic properties, and both classical and contemporary synthetic methodologies. Special emphasis is placed on modern approaches such as multicomponent reactions, metal-catalyzed processes, and green chemistry strategies. Furthermore, the biological activities of quinazoline derivatives are discussed in detail, with attention to their mechanisms of action, molecular targets, and structure