Current Advances in Immunotherapy for Solid Tumors

Description

This book provides a comprehensive overview of the latest advances in immunotherapy for solid tumors, covering both foundational concepts and cutting-edge therapeutic strategies. It begins with an introduction to immunotherapy and explores the mechanisms by which solid tumors evade immune responses, including the immunosuppressive microenvironment, immune checkpoints, and tumor antigen variability. The subsequent chapters delve into specific immunotherapeutic approaches, such as immune checkpoint inhibitors (PD-1/PD-L1 and CTLA-4 inhibitors), cellular therapies (CAR-T, CAR-NK, TCR-T, TIL, and CAR-M therapies), tumor vaccines, and bispecific antibody engagers. Each chapter discusses the construction, mechanisms, clinical applications, successes, challenges, and future directions of these therapies. The book concludes with an examination of combination therapy strategies, highlighting synergies between immunotherapy and chemotherapy, radiotherapy, and multi-targeted treatments. With its systematic and in-depth coverage, this book serves as a valuable resource for researchers, clinicians, and students seeking to understand and advance the field of cancer immunotherapy.